Aster Posted on Aug 04 2016 at 2:28 pm
This paper describes the determination of the pKa of a chemical substance that is insoluble in water based on solubility profile elaborated from the Yasuda-Shedlovsky experiment. Specifically, a chiral chromatographic method was developed to quantify the enantiomers in solution. By combining the chiral chromatographic method and Mat-pKa software calculation, pKa of the non-hydro-soluble compound can be determined.
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