91桃色

Abstract

Healthcare-associated infections (HAIs) pose a significant threat to patient safety, with multidrug-resistant (MDR) pathogens exacerbating the challenge of effective treatment. Antibiotic stewardship programs (ASPs) have emerged as a crucial strategy in mitigating HAIs by promoting the appropriate use of antimicrobial agents, reducing antibiotic overuse, and minimizing the development of resistance. These programs focus on optimizing antibiotic selection, dosage, and duration while integrating infection prevention measures such as hand hygiene, environmental cleaning, and surveillance. Evidence suggests that ASPs contribute to a decline in HAIs caused by resistant bacteria such as Clostridioides difficile, Methicillin-resistant Staphylococcus aureus (MRSA), and carbapenem-resistant Enterobacterales (CRE). Furthermore, multidisciplinary approaches involving healthcare professionals, microbiologists, and policymakers enhance the effectiveness of stewardship initiatives. Despite their success, challenges such as limited resources, poor adherence, and the emergence of novel resistance mechanisms highlight the need for continuous improvement and global collaboration. Strengthening ASPs through education, rapid diagnostics, and policy enforcement will be essential in reducing HAIs and preserving the efficacy of existing antibiotics.