Case Report
Ceftriaxone-Associated Cholelithiasis in Adult Patients with Bacterial Meningitis
| Hideto Nakajima*, Shin Ota, Takahiko Hirose, Takafumi Hosokawa, Shimon Ishida and Fumiharu Kimura | ||
| Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan | ||
| Corresponding Author : | Hideto Nakajima Division of Neurology Department of Internal Medicine I Osaka Medical College, Takatsuki Osaka 569-8686, Japan Tel: +81-72-683-1221 Fax: +81-72-683-1801 E-mail: in1045@poh.osaka-med.ac.jp |
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| Received August 01, 2014; Accepted August 26, 2014; Published August 30, 2014 | ||
| Citation: Nakajima H, Ota S, Hirose T, Hosokawa T, Ishida S, Kimura F (2014) Ceftriaxone-Associated Cholelithiasis in Adult Patients with Bacterial Meningitis. J Infect Dis Ther 2:161. doi: 10.4172/2332-0877.1000161 | ||
| Copyright: © 2014 Nakajima H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||
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Abstract
Ceftriaxone is known to induce gallstones and intrabiliary debris as the adverse effects. Ceftriaxone-related cholelithiasis occurs mainly in children treated with a high dosage of ceftriaxone for severe infections and has been rarely reported in adults. Here we report two cases of bacterial meningitis, with cholelithiasis complication developed during ceftriaxone treatment. A 65 year old man and a 66 year old man were treated with long-term (3 weeks) administration of high-dose ceftriaxone (4 g/day) for bacterial meningitis. Both patients had renal dysfunction, which may have affected gallstone formation. In one patient, gallstones spontaneously disappeared after discontinuing ceftriaxone treatment. However, the other patient needed the drainage by endoscopic retrograde cholangiopancreatography. These events are associated with elevated doses of ceftriaxone and require particular attention in the elderly and patients with .
