Cellular Senescence as a Key Player in Chronic Heart Failure Pathogenesis: Unraveling Mechanisms and Therapeutic Opportunities

Ying  Zhao; Xiaohui  Lu; Shuqing  Zhao; Yu  Zhang

1165-158X

Cellular and Molecular Biology
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Review Article
Cell Mol Biol ,

Cellular Senescence as a Key Player in Chronic Heart Failure Pathogenesis: Unraveling Mechanisms and Therapeutic Opportunities

Ying Zhao¹^*, Xiaohui Lu¹^*, Shuqing Zhao² and Yu Zhang³: ¹Department of Geotechnical and Structural Engineering Research Center, Shandong University of Traditional Chinese Medicine, Jinan, China; ²Department of Molecular Biology, Shandong University of Traditional Chinese Medicine, Jinan, China; ³Department of Biomedical Engineering, Shandong University of Traditional Chinese Medicine, Jinan, China

^*Corresponding Author (s) : Ying Zhao, Department of Geotechnical and Structural Engineering Research Center, Shandong University of Traditional Chinese Medicine, Jinan, China, Email: sdwfclyn@163.com

Xiaohui Lu, Department of Geotechnical and Structural Engineering Research Center, Shandong University of Traditional Chinese Medicine, Jinan, China, Email: lxhtcm@126.com

Received Date: Apr 12, 2024 / Published Date: May 14, 2024

Abstract

Chronic Heart Failure (CHF) is the final stage of heart disease and can be caused by a variety of factors in clinical practice. Unfortunately, CHF has a poor prognosis and a high mortality rate. Recent studies have found that aging is a significant risk factor for developing CHF and that cellular senescence plays a vital role in its development. Therefore, this article reviews the role and therapeutic progress of cellular senescence in CHF from different types of cellular senescence, mitochondrial dysfunction in senescent cells, autophagy in senescent cells, and Senescence-Associated Secretory Phenotype (SASP), to provide new perspectives on the research and treatment of CHF.

Keywords: Chronic heart failure; Senescence-associated secretory phenotype; Mitochondrial dysfunction; 2’-deoxyadenosine

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Citation: Zhao Y, Lu X, Zhao S, Zhang Y (2024) Cellular Senescence as a Key Player in Chronic Heart Failure Pathogenesis: Unraveling Mechanisms and Therapeutic Opportunities. Cell Mol Biol S2:001.

Copyright: © 2024 Zhao Y et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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