Case Report
Complete Remission of Primary Cutaneous Cryptococcosis in an Immunosuppressed Patient after Fluconazole Treatment
Landucci G1, Farinelli P2, Zavattaro E3*, Giorgione R2, Gironi LC2, Veronese F1, Astolfi S2, Tiberio R2, Boldorini RL1, Colombo E3 and Savoia P1
1Department of Health Sciences, University of Eastern Piedmont, Novara, Italy
2Maggiore della Carita University-Hospital, Novara, Italy
3Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
- *Corresponding Author:
- Elisa Zavattaro
Department of Translational Medicine
University of Eastern Piedmont
Via Solaroli 17, 28100, Novara, Italy
Tel: 39 0321 3733269
Fax: 39 0321 3733586
E-mail: elisa.zavattaro@med.uniupo.it
Received date: June 25, 2017; Accepted date: July 20, 2017; Published date: July 26, 2017
Citation: Landucci G, Farinelli P, Zavattaro E, Giorgione R, Gironi LC, et al. (2017) Complete Remission of Primary Cutaneous Cryptococcosis in an Immunosuppressed Patient after Fluconazole Treatment. J Infect Dis Ther 5:326. doi: 10.4172/2332-0877.1000326
Copyright: © 2017 Zavattaro E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Cryptococcus neoformans is opportunistic encapsulated yeast that represents the most frequent cryptococcal species found in humans. It can cause three types of infections: pulmonary cryptococcosis, and cutaneous cryptococcosis. Cutaneous cryptococcosis may represent the dissemination of a systemic infection (especially from nervous or pulmonary primary site of infection) or may be the only localization, due to a direct inoculation into the skin, because of a traumatic injury. Primary cutaneous cryptococcosis (PCC) is rare and mainly affects elderly patients, from rural areas, with history of cutaneous injuries and activities predisposing wounds or exposure to bird droppings. Immunosuppression may be a predisponing factor. The most utilized treatment is fluconazole, but often, especially for ulcers or deep wounds; surgery is required for complete tissues repair. Herein, we present a case of PCC in an immunosuppressed patient, with destroying ulcers involving deep tissues, completely resolved after fluconazole treatment, without surgical intervention.
