Research Article
Cyclin D1 G870A Polymorphism is Associated with an Increased Risk of Simple Endometrial Hyperplasia in Egyptian Women
| Abdel Aziz A F1*, El-Refaeey A A2, Afaf M Elsaeid3 and Manar Refaat1 | |
| 1Biochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Egypt | |
| 2Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt | |
| 3Genetic Unit, Department of Pediatrics, Faculty of medicine, Mansoura University, Mansoura, Egypt | |
| *Corresponding Author : | Abdel-Aziz Mohammed A F Professor/Consultant of Biochemistry Faculty of Science, Mansoura University, Mansoura, Egypt Tel: +201008764445 / 20502223380 E-mail: afaziz@mans.edu.eg or afaziz2012@hotmail.com |
| Received December 15, 2013; Accepted January 27, 2014; Published January 31, 2014 | |
| Citation: Abdel Aziz AF, El-RefaeeyAA, Elsaeid AM, Refaat M (2014) Cyclin D1 G870A Polymorphism is Associated with an Increased Risk of Simple Endometrial Hyperplasia in Egyptian Women. Biochem Physiol 3:123. doi:10.4172/2168- 9652.1000123 | |
| Copyright: © 2014 Abdel Aziz AF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Endometrial hyperplasia (EH) is a common diagnosis in women presenting with abnormal uterine bleeding, leading to cancer if untreated. Cyclin D1 A870G polymorphism was associated with increased risk of endometrial carcinoma, but no reported study has evaluated the association between the cyclin D1 A870G polymorphism and the risk of EH. We aimed to study the association of cyclin D1 A870G polymorphism with the risk of simple endometrial hyperplasia (SEH) in Egyptian women. Results showed that A allele was associated with a significantly elevated OR of 3.2 (95% CI =2.15 -5.01, P = 0.0001) in SEH cases, and was found to be associated with a significantly elevated OR of 4.03 (95% CI = 2.3 -7.1, P = 0.000) in premenopausal cases, as well as postmenopausal cases (OR of 2.3, 95% CI = 1.18-4.4, P = 0.01). Using the GG genotype as the reference genotype, the AA genotype was associated with a significantly elevated OR of 8.9 (95% CI = 3.7-21.5, P = 0.0001) in SEH cases, and was found to be associated with a significantly elevated OR of 16.4 (95% CI = 4.8-55.5, P = 0.000) in premenopausal cases as well as post-menopausal cases (OR of 4.6 (95% CI = 1.18-18.1, P = 0.02). In conclusion, the common G to A polymorphism in the CCND1 gene is associated with an increased risk of simple endometrial hyperplasia.
