91桃色

Abstract

Surface-Enhanced Raman Spectroscopy (SERS) has emerged as a powerful bioanalytical tool for detecting specific molecular interactions with exceptional sensitivity and specificity. By amplifying the Raman scattering signals of molecules near nanostructured metallic surfaces, SERS enables the identification and characterization of biomolecules such as proteins, nucleic acids, and small metabolites at trace concentrations. This article explores the recent advancements in SERS substrates, instrumentation, and data analysis techniques, focusing on their applications in medical diagnostics, environmental monitoring, and biochemical research. Results from cutting-edge studies demonstrate SERS’s ability to detect disease biomarkers, monitor biomolecular binding events, and probe cellular processes in real time. While challenges such as reproducibility and substrate stability remain, ongoing innovations promise to expand SERS’s role in bio analysis, offering a pathway to precision diagnostics and deeper insights into molecular dynamics.