Fluorescent Pore-Former Suggests an Approach for the Enhancement of Antibiotic Efficacy

George W Gokel; Nichole S Curvey; Michael R Gokel; Matthew E Lindsay; Joseph L Meisel; Saeedeh Negin; Mohit B Patel; Sergey Sedinkin

doi:10.4172/2090-4967.1000103

ISSN: 2090-4967

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Review Article
Biosens J 2013 2:103,
DOI: 10.4172/2090-4967.1000103

Fluorescent Pore-Former Suggests an Approach for the Enhancement of Antibiotic Efficacy

George W Gokel^*, Nichole S Curvey, Michael R Gokel, Matthew E Lindsay, Joseph L Meisel, Saeedeh Negin, Mohit B Patel and Sergey Sedinkin: Center for Nanoscience, Departments of Chemistry and Biochemistry and Biology, University of Missouri, St. Louis, University Blvd., St. Louis, MO 63121, USA

^*Corresponding Author : George W Gokel, Center for Nanoscience, Departments of Chemistry and Biochemistry and Biology,Department of Chemistry and Biochemistry, University of Missouri, St. Louis, USA, Tel: 314/516-5321, Fax: 314/516-5342, Email: gokelg@umsl.edu

Received Date: Sep 03, 2013 / Accepted Date: Sep 27, 2013 / Published Date: Oct 08, 2013

Abstract

A hydraphile channel having fluorescent dansyl side chains inserts into bacterial bilayers. The combination of nontoxic concentrations of hydraphiles and erythromycin enhances the efficacy of this antibiotic against Gram negative E. coli and P. aeruginosa.

Keywords: Amphiphile; Antibiotic; Bacteria; Erythromycin; Hydraphile; Synthetic channel

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Citation: Gokel GW, Curvey NS, Gokel MR, Lindsey Meisel JW, Meisel JL, et al. (2013) Fluorescent Pore-Former Suggests an Approach for the Enhancement of Antibiotic Efficacy. Biosens J 2:103. Doi: 10.4172/2090-4967.1000103

Copyright: © 2013 Gokel GW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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