Human Leukocyte Antigen G as a Novel Target for Switch-based Chimeric Antigen Receptor Natural Killer Cell Therapy of Solid Cancer
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Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Challenges present with chimeric antigen receptors (CARs) adoptive cell therapy against solid tumors have been lacking a ubiquitous tumor-associated antigen across different tumor types, tumor antigen expression heterogeneity, and the immunosuppressive nonphysical tumor microenvironment. Thus, we developed a switch anti human leukocyte antigen (HLA)-G CAR that binds to HLA-G1~G7
