Impact of Genetic Variability on Drug Response in Cancer Therapy: Recent Findings and Clinical Applications
Received Date: Jul 27, 2024 / Published Date: Aug 26, 2024
Abstract
Genetic variability significantly influences drug response in cancer therapy, affecting both efficacy and toxicity. This review explores recent findings on how genetic differences impact the metabolism, effectiveness, and safety of cancer treatments. Key genetic markers, such as polymorphisms in drug-metabolizing enzymes (e.g., CYP450, UGT1A1) and drug targets (e.g., EGFR, KRAS), are discussed in relation to their clinical implications. Advances in pharmacogenomics have provided insights into optimizing treatment strategies and minimizing adverse effects through personalized medicine approaches. The integration of genetic information into clinical practice holds promise for enhancing patient outcomes and tailoring cancer therapies to individual genetic profiles
Citation: Santosh KS (2024) Impact of Genetic Variability on Drug Responsein Cancer Therapy: Recent Findings and Clinical Applications Clin PharmacolBiopharm, 13: 480.
Copyright: © 2024 Santosh KS. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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