Radiotherapy for Large Single Brain Metastasis of Non Small Cell Lung
Abstract
Brain metastases are more common than all other primary intracranial tumors [1-3]. Lung cancer is the most common primary site [4-6]. Approximately 20– 50% of patients present with a single lesion in the brain. Patients with a single brain metastasis from non-small cell lung cancer (NSCLC) have the potential for long term survival [7,8]. Treatment for this lesion includes some combination of steroids, whole-brain radiation therapy (WBRT), local radiation therapy including stereotactic radiosurgery (SRS), and surgical resection. The management for these patients is controversial. Although radiation therapy is non-invasive, whole brain radiation therapy have some brain toxicities. This shifted away from whole brain radiation therapy (WBRT) toward local treatment modalities including radiosurgery (RS) and fractionated stereotactic radiation therapy (FSRT) [9-11].
