Update on Fungal Disease: From Establish Infection to Clinical Manifestation
Received Date: Aug 15, 2017 / Accepted Date: Sep 18, 2017 / Published Date: Oct 25, 2017
Abstract
Fungal diseases have emerged as an important cause of morbidity and mortality, especially among immunocompromised patients. Pathogenic fungi have evolved an array of virulence factors to survive within the host and to outwit immune defenses. Fungi may cause a wide range of diseases in humans that range in extent from superficial to disseminated infections. Generally, the site of infections classifies the type of fungal disease, which can be divided into superficial, cutaneous, subcutaneous and systemic. In addition, the fungal virulence factors determine whether the infection will become established in the host. A primary pathogen may infect an immunologically normal host, whereas, an opportunistic pathogen requires some compromise of the host immune defenses in order for the infection to become established. This article covers the main fungi that are responsible for the increase of the fungal infections.
Keywords: Fungal infections; Virulence; Yeast; Opportunistic infections; Endemic mycosis
Citation: de Melo WCMA, Scorzoni L, Rossi SA, Costa-Orlandi CB, Yonashiro M, et al. (2017) Update on Fungal Disease: From Establish Infection to Clinical Manifestation. J Biotechnol Biomater 7: 273. Doi: 10.4172/2155-952X.1000273
Copyright: 2017 de Melo WCMA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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