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Abstract

Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of chitosan and its derivatives and calcium phosphates has grown significantly over the last two decades due to its renewable and biodegradable source, increasing in the knowledge of its functionality in the technological and biomedical applications. The properties of bone in health and disease attract much attention. With an ever greater proportion of the population need those medical devices for hard tissue regeneration and/or replacement, making the pressure on the health systems in all countries. Aging, diseases, fractures and demineralization are musculoskeletal disorder, which contribute and improve the suitability and developments of new materials and methods in hard tissue engineering. The excellent biocompatibility, biofunctionality, and non-antigenic property make those materials a good choice for hard tissue regeneration. This work has shown the composites of chitosan and its derivatives with calcium phosphates in different forms (sponge, fibres) containing organic and inorganic materials, including chemical characterisation, mechanical properties, particles size, morphology, solution stability and also a new method to obtain nanoceramic formation in chitosan solution. All sponge preparations, with MCCh/Ã?Â?-TCP have a well-shaped 3-dimentional structure, a highly porosity and interconnected, homogenous pore structure to ensure a biological environment conducive to cells attachment and proliferation and passage of nutrient flow. The fibres form showed nanoceramic formation with two different kinds of calcium phosphates, great mechanical properties performance in wet conditions and not finishing agent was required in the wet spinning process of fabrication. These materials can be used in future for medical applications as a base for scaffolds production as implants in regenerative medicine.

Biography

Email: lpighinelli@hotmail.com pighinelli@gmail.com