ISSN: 2167-065X
Clinical Pharmacology & Biopharmaceutics
Open 91桃色
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open 91桃色 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open 91桃色 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 1089
Indexed In
- CAS Source Index (CASSI)
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Genamics JournalSeek
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Determination of some non-sedating antihistamines via their native fluorescence and derivation of some quantitative fluorescence intensity - structure relationships
Pharma Middle East
Noha M Hosny, Michael E El-Kommos, Samia M El-Gizawy and Noha N Atia
Assiut University, Egypt
Posters-Accepted Abstracts: Clin Pharmacol Biopharm
DOI:
Abstract
A validated simple, novel, and rapid spectro-fluorimetric method was developed for the determination of some Non-Sedating Antihistamines (NSAs); namely Cetirizine (CTZ), Ebastine (EBS), Fexofenadine (FXD), and Loratadine (LOR). The method is based on measuring the native fluorescence of the cited drugs after protonation in acidic media and studying their quantitative fluorescence intensity 芒�?�? structure relationships. There was a linear relationship between the relative fluorescence intensity and the concentration of the investigated drug. Under the optimal conditions, the linear ranges of calibration curves for the determination of the studied NSAs were 0.10芒�?�?2.0, 0.20芒�?�?6.0, and 0.02芒�?�?1.0 �?录g/mL for (CTZ, FXD), (EBS), and (LOR); respectively. The factors affecting the protonation of the studied drugs were carefully studied and optimized. The method was validated according to ICH guidelines. The suggested method is applicable for the determination of the four investigated drugs in bulk and pharmaceutical dosage forms with excellent recoveries (97.67 - 103.80%). Quantitative relationships were found between the relative fluorescence intensities of the protonated drugs and their physicochemical parameters namely: the pKa, log P, connectivity indexes (脧�?v) and their squares. Regression equations (76) were obtained and not previously reported. Six of these equations were highly significant and used for the prediction of RFI of the studied NSAs.Biography
Email: phar_nmh2011@yahoo.com
