ISSN:2167-7964
Journal of Radiology
Open 91桃色
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open 91桃色 Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open 91桃色 Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 551
Indexed In
- Index Copernicus
- Google Scholar
- Open J Gate
- Genamics JournalSeek
- ResearchBible
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- ICMJE
Useful Links
Share This Page
Leptin gene polymorphisms as a biomarker in obese breast cancer patients
3rd International Conference on Radiology and Imaging
Kaiser Jamil
Centre for Biotechnology and Bioinformatics, India Nizam芒�?�?s Institute of Medical Sciences, India Bhagwan Mahavir Medical Research Center, India
Posters-Accepted Abstracts: OMICS J Radiol
DOI:
Abstract
Background: Leptin plays an important role in mammary tumor formation. It is secreted by adipose tissue that acts at the brain to regulate energy expenditure and food intake and has an important role in energy balance, insulin pathway and inflammation. Hence the aim of our investigation has been on the impact of Lep-2548G/A polymorphism in breast cancer as compared to matched control. Patients & Methods: The present study focuses on the polymorphism leptin gene for variants by screening of this gene in South Indian obese subjects (n=154 obese breast cancer cases and n=145 obese controls). We utilized PCR- RFLP based assay to evaluate the association between the Gln2548Arg polymorphism of the leptin gene and breast cancer risk in case control study. Results & Discussion: The distributions of all three genotypes in breast cancer cases were 18.8%, 44.8%, and 36.4% compared to that of the controls, 33.0%, 29.6%, and 37.4%. We found that postmenopausal breast cancer cases showed statistically significant association with GA genotype when compared with premenopausal women without disease (p=0.001). This difference was between the cases and controls in the Gln2548Arg genotypes. Conclusion: Our findings suggest that the LEP Gln2548Arg polymorphism may be a useful biomarker associated with the risk of breast cancer women in Indian population.Biography
Email:
kj.bmmrc@gmail.com