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The prognostic value of 24-hour urine sodium (24-hr una) in cirrhotic patients with ascites on diuretics
Joint Event on 13th International Conference on Pediatric Gastroenterology Hepatology & Nutrition & 3rd International Conference on Digestive and Metabolic Diseases
Background: Ascites due to cirrhosis can be mobilized with sodium restriction (88 mEq/day) and diuretics.Patients with
non-responder to diuretics may have pre-hepatorenal syndrome and a poor prognosis.Diuretic response can be monitored by
measuring 24-hr UNa which can also be a prognostic marker.The aim of this study was to evaluate the value of 24-hr UNa as
a prognostic marker in cirrhotic patient with ascites on diuretics.
Methods: This cross-sectional study included 100 patients of cirrhosis on diuretics.24-hour urine was collected properly and
tested accordingly.At the same time liver and renal function tests were done to calculate MELD and CTP score.
Results: Out of 100, 48 (48%) subjects had excreted 鈮78 mmol/d of sodium and 52 (52%) subjects excreted <78mmol/d.64
subjects belong to CTPS 鈥淏鈥 and 36 in CTPS 鈥淐鈥漡roup.Majority of the cases (81.3%)of CTPS 鈥淏鈥 group had excreted 鈮78 mmol
sodium/day and 51.9% patients of the CTPS 鈥淐鈥 group had 24hr urinary sodium <78 mmol/day.In patients who excreted <
78 mmol/day MELD score was 17.71 卤 4.51 and it was 14.60 卤 2.98 in patients who excreted 鈮78mmol/day of urinary sodium.
These differences were statistically significant (p<0.001).
Conclusion: This study showed that advanced cirrhosis have relatively lower natriuresis in response to diuretics.So, 24-hr UNa
can be considered as a prognostic indicator.But multicentered studies are needed for further recommendation.