91桃色

Abstract

The treatment of damaged, disease or non-functional tissue and organs through tissue engineering is still a major challenge. Within this context, recent advances in the development of biomaterials for regenerative medicine and the combination of fabrication techniques, such as 3D Printing, have allowed the three-dimensional fabrication of biocompatible matrices with a great precision, which can be associated with cells and bioactive molecules. The association of cells could be improved in a 3D cell organization in a form of building blocks called spheroids, which can closely mimic the natural microenvironment of organs and tissues, consisting of an attractive approach for the development of tissue engineering and cell therapies. Then, with the tissue engineering techniques combined with the information technology and engineering aspects, homogeneous spheroids could be obtained. These spheroids could be placed in a 3D bioprinting, in which the tissues manufacturing aspects could be precisiously controlled. This technology permits the biofabrication in different shapes, with sophisticated geometry and when combined with bioactive agents could promote the functionalization of the tissues. The area which combines all those fields cited before is called biofabrication, which is growing, maturing and receiving the collaboration of scientists with various backgrounds, characterizing its multidisciplinary aspect. Nowadays, one of the main bottlenecks of biofabrication is to promote the synergy and integration of all those techniques, which is a huge challenge.

Biography

E-mail: monizedecarli@gmail.com